Wine is a free solution for running MetaTrader and other Windows app's on a Mac. I've tried it before and found it to be more annoying than helpful, so removed it. It's easier to stick with a Windows OS for MetaTrader, in my humble opinion, so rather use something like Parallels or BootCamp on a Mac ... if you don't mind paying for a Windows licence. ... or use a VPS.
Two traders have got in contact this week to say they couldn't load some indicators on to their charts, where previously they had no issues. Each had a problem with a different indicator that displays perfectly well in the navigator window but just couldn't be applied to the chart.
I'm no Wine expert, at least not the type of wine we're talking about here, thus regret I'm unable to help with these problems or guarantee that any of the products that I've coded will work with Wine. Good news though: one of the traders has found a solution with VirtualBox. I've not used it before but he reports that MetaTrader is now working perfectly and all the indicators are loading without issue. So, if you do find similar issues please google VirtualBox and give that a go.